October 1, 2024

Children experience dramatic brain aging


National Institute of Pediatrics, Mexico City
Source: Toxicology Pathologies, Feb 2008

View ONLINE or Download PDF

Autopsies were performed on 35 healthy children and young adults who died suddenly in cities with high air pollution and compared to 12 control individuals who died in cities with low air pollution. Those in high air pollution cities had higher inflammation markers in the brain, disruption of the blood brain barrier and elevated brain cell death from free radicals in a process known as "oxidative stress." There was also an increase in amyloid beta proteins (common in Alzheimers), increased particulate matter in the brain's olfactory bulb neurons and accumulation of vehicle exhaust particulate matter in the lungs and capillaries. Researchers concluded by stating that air pollution (as from vehicle traffic) should be considered a risk for Alzheimer's Disease.

ABSTRACT
Air pollution is a serious environmental problem. We investigated whether residency in cities with high air pollution is associated with neuroinflammation/neurodegeneration in healthy children and young adults who died suddenly. We measured mRNA cyclooxygenase-2, interleukin-1β, and CD14 in target brain regions from low (n = 12) or highly exposed residents (n = 35) aged 25.1 ± 1.5 years. Upregulation of cyclooxygenase-2, interleukin-1β, and CD14 in olfactory bulb, frontal cortex, substantia nigrae and vagus nerves; disruption of the blood-brain barrier; endothelial activation, oxidative stress, and inflammatory cell trafficking were seen in highly exposed subjects. Amyloid β42 (Aβ42) immunoreactivity was observed in 58.8% of apolipoprotein E (APOE) 3/3 < 25 y, and 100% of the APOE 4 subjects, whereas α-synuclein was seen in 23.5% of < 25 y subjects. Particulate material (PM) was seen in olfactory bulb neurons, and PM < 100 nm were observed in intraluminal erythrocytes from lung, frontal, and trigeminal ganglia capillaries.

Exposure to air pollution causes neuroinflammation, an altered brain innate immune response, and accumulation of Aβ42 and α-synuclein starting in childhood. Exposure to air pollution should be considered a risk factor for Alzheimer’s and Parkinson’s diseases, and carriers of the APOE 4 allele could have a higher risk of developing Alzheimer’s disease if they reside in a polluted environment.

View another category from the menu above.